Quantum-Enhanced Brain Tumor Detection and Progression Prediction Using MRI Imaging

  • Malige Gangappa VNR Vignana Jyothi Institute of Engineering and Technology
  • D Manju Department of Department of CSE-(CyS,DS) and AI&DS, VNR VJIET, Hyderabad, India
  • Maringanti Gopi Krishnna Department of CSE, VNR VJIET, Hyderabad-500090, Telangana, India
  • M. Sree Mithra Reddy Department of CSE, VNR VJIET, Hyderabad-500090, Telangana, India
  • M. Sathish Department of CSE, VNR VJIET, Hyderabad-500090, Telangana, India
  • Sk Shahabaaz Department of CSE, VNR VJIET, Hyderabad-500090, Telangana, India
  • A. Shanthan Department of CSE, VNR VJIET, Hyderabad-500090, Telangana, India
  • M. Chaitanya Department of Computer science and engineering, IARE, Dundigle , Hyderabad, India
Keywords: BraTS Dataset, Brain Tumor Detection, Magnetic Resonance Imaging (MRI), Medical Image Segmentation, Quantum Convolutional Neural Network (QCNN), Quantum Feature Maps, Tumor Progression Prediction.

Abstract

Brain tumor identification and change over time analysis are essential for timely diagnosis and effective treatment scheduling and planing. This study presents a hybrid quantum-classical deep learning framework integrating Quantum Convolutional Neural Networks (QCNNs) with classical CNN to improve MRI-based tumor classification. Unlike traditional CNNs, which suffer from high computational costs and limited feature extraction capabilities, the proposed Quantum-Enhanced Tumor Analysis Framework (QETAF) leverages quantum feature maps to enhance tumor localization and segmentation. This study utilizes the BraTS MRI dataset (comprising 67,000 labeled scans) and applies contrast enhancement, intensity normalization, and augmentation techniques for preprocessing. The novel hybrid model employs CNN model for extracting the essential features initially and QCNN for refined feature representation, significantly improving tumor classification accuracy. Moreover, morphological variations can be monitored using Recurrent Quantum Neural Networks (RQNNs), which have been employed to track tumor progression. According to investigational results, RQNN increases the accuracy of tumor progress prediction, whereas QCNN beats regular CNNs with an 89% Dice Coefficient. Compared to classical models, the proposed approach reduces inference time by 28% while maintaining superior classification performance. This quantum-assisted model presents a novel pathway for enhancing computational efficiency and precision in brain tumor diagnostics, covering the way for more consistent clinical diagnostics.

Downloads

Download data is not yet available.

References

J. Amin, M. Sharif, M. Yasmin, and S. L. Fernandes, “Big data analysis for brain tumor detection: Deep convolutional neural networks,” Future Generation Computer Systems, vol. 87, pp. 290–297, Oct. 2018, doi: 10.1016/J.FUTURE.2018.04.065.

F. Ullah et al., “Brain Tumor Segmentation from MRI Images Using Handcrafted Convolutional Neural Network,” Diagnostics 2023, Vol. 13, Page 2650, vol. 13, no. 16, p. 2650, Aug. 2023, doi: 10.3390/DIAGNOSTICS13162650.

G. Litjens et al., “Computed Tomography-Based Radiomics Using Tumor and Vessel Features to Assess Resectability in Cancer of the Pancreatic Head,” Diagnostics, vol. 13, no. 20, p. 3198, Oct. 2023, doi: 10.3390/DIAGNOSTICS13203198/S1.

A. B. Abdusalomov, M. Mukhiddinov, and T. K. Whangbo, “Brain Tumor Detection Based on Deep Learning Approaches and Magnetic Resonance Imaging,” Cancers (Basel), vol. 15, no. 16, Aug. 2023, doi: 10.3390/CANCERS15164172.

H. Sultan et al., “MDFU-Net: Multiscale dilated features up-sampling network for accurate segmentation of tumor from heterogeneous brain data,” Journal of King Saud University - Computer and Information Sciences, vol. 35, no. 5, p. 101560, May 2023, doi: 10.1016/J.JKSUCI.2023.101560.

M. Nurgazin and N. A. Tu, “A Comparative Study of Vision Transformer Encoders and Few-shot Learning for Medical Image Classification,” Proceedings - 2023 IEEE/CVF International Conference on Computer Vision Workshops, ICCVW 2023, pp. 2505–2513, 2023, doi: 10.1109/ICCVW60793.2023.00265.

A. Makhlouf, M. Maayah, N. Abughanam, and C. Catal, “The use of generative adversarial networks in medical image augmentation,” Neural Comput Appl, vol. 35, no. 34, pp. 24055–24068, Dec. 2023, doi: 10.1007/S00521-023-09100-Z/FIGURES/7.

Z. Rasheed et al., “Automated Classification of Brain Tumors from Magnetic Resonance Imaging Using Deep Learning,” Brain Sci, vol. 13, no. 4, Apr. 2023, doi: 10.3390/BRAINSCI13040602.

D. Shen, G. Wu, and H. Il Suk, “Deep Learning in Medical Image Analysis,” Annu Rev Biomed Eng, vol. 19, pp. 221–248, Jun. 2017, doi: 10.1146/ANNUREV-BIOENG-071516-044442.

J. N. Stember and H. Shalu, “Reinforcement learning using Deep Q networks and Q learning accurately localizes brain tumors on MRI with very small training sets,” BMC Med Imaging, vol. 22, no. 1, pp. 1–8, Dec. 2022, doi: 10.1186/S12880-022-00919-X/FIGURES/4.

N. Amanova, “A novel explainability method with application to mammography image quality assessment,” 2024, doi: 10.14279/DEPOSITONCE-20591.

M. Al-Zafar, ¶∥ K., N. Innan, A. Al, O. Galib, and M. Bennai, “Brain Tumor Diagnosis Using Quantum Convolutional Neural Networks,” Jan. 2024, Accessed: Apr. 14, 2025. [Online]. Available: http://arxiv.org/abs/2401.15804

D. Konar, E. Gelenbe, S. Bhandary, A. Das Sarma, and A. Cangi, “Random Quantum Neural Networks (RQNN) for Noisy Image Recognition,” Proceedings - 2023 IEEE International Conference on Quantum Computing and Engineering, QCE 2023, vol. 2, pp. 276–277, Mar. 2022, doi: 10.1109/QCE57702.2023.10240.

M. Schuld and F. Petruccione, “Supervised Learning with Quantum Computers,” 2018, doi: 10.1007/978-3-319-96424-9.

D. Konar, S. Bhattacharyya, B. K. Panigrahi, and E. C. Behrman, “Qutrit-inspired Fully Self-supervised Shallow Quantum Learning Network for Brain Tumor Segmentation,” IEEE Trans Neural Netw Learn Syst, vol. 33, no. 11, pp. 6331–6345, Nov. 2022, doi: 10.1109/TNNLS.2021.3077188.

V. Dunjko and H. J. Briegel, “Machine learning & artificial intelligence in the quantum domain: a review of recent progress,” Reports on Progress in Physics, vol. 81, no. 7, p. 074001, Jun. 2018, doi: 10.1088/1361-6633/AAB406.

J. Biamonte, P. Wittek, N. Pancotti, P. Rebentrost, N. Wiebe, and S. Lloyd, “Quantum Machine Learning,” Nature, vol. 549, no. 7671, pp. 195–202, Nov. 2016, doi: 10.1038/nature23474.

S. Banerjee, S. Mitra, F. Masulli, and S. Rovetta, “Deep Radiomics for Brain Tumor Detection and Classification from Multi-Sequence MRI,” Mar. 2019, Accessed: Apr. 14, 2025. [Online]. Available: https://arxiv.org/abs/1903.09240v1

B. Bauer, S. Bravyi, M. Motta, and G. Kin-Lic Chan, “Quantum Algorithms for Quantum Chemistry and Quantum Materials Science,” Chem Rev, vol. 120, no. 22, pp. 12685–12717, Nov. 2020, doi: 10.1021/ACS.CHEMREV.9B00829/ASSET/IMAGES/MEDIUM/CR9B00829_0023.GIF.

X. Pei et al., “Robustness of machine learning to color, size change, normalization, and image enhancement on micrograph datasets with large sample differences,” Mater Des, vol. 232, p. 112086, Aug. 2023, doi: 10.1016/J.MATDES.2023.112086.

T. Dou, G. Zhang, and W. Cui, “Efficient Quantum Feature Extraction for CNN-based Learning,” J Franklin Inst, vol. 360, no. 11, pp. 7438–7456, Jan. 2022, doi: 10.1016/j.jfranklin.2023.06.003.

S. Sivarajkumar et al., “Automating the detection of treatment progression in patients with lung cancer using large language models.,” Journal of Clinical Oncology, vol. 42, no. 16_suppl, pp. e13620–e13620, Jun. 2024, doi: 10.1200/JCO.2024.42.16_SUPPL.E13620.

Y. Lu, Q. Gao, J. Lu, M. Ogorzalek, and J. Zheng, “A Quantum Convolutional Neural Network for Image Classification,” Chinese Control Conference, CCC, vol. 2021-July, pp. 6329–6334, Jul. 2021, doi: 10.23919/CCC52363.2021.9550027.

M. Mager et al., “GPT-too: A language-model-first approach for AMR-to-text generation,” Proceedings of the Annual Meeting of the Association for Computational Linguistics, pp. 1846–1852, May 2020, doi: 10.18653/v1/2020.acl-main.167.

M. Gangappa, “Feature level fusion for land cover classification with landsat images: A hybrid classification model,” Multiagent and Grid Systems, vol. 19, no. 2, pp. 149–168, Oct. 2023, doi: 10.3233/MGS-230034.

B. H. Menze et al., “A Generative Probabilistic Model and Discriminative Extensions for Brain Lesion Segmentation - With Application to Tumor and Stroke,” IEEE Trans Med Imaging, vol. 35, no. 4, pp. 933–946, Apr. 2016, doi: 10.1109/TMI.2015.2502596.

S. Bakas et al., “Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge,” Nov. 2018, Accessed: Apr. 14, 2025. [Online]. Available: https://arxiv.org/abs/1811.02629v3

“Enhanced performance of Dark-Nets for brain tumor classification and segmentation using colormap-based superpixel techniques - Amrita Vishwa Vidyapeetham.” Accessed: Apr. 14, 2025. [Online]. Available: https://www.amrita.edu/publication/enhanced-performance-of-dark-nets-for-brain-tumor-classification-and-segmentation-using-colormap-based-superpixel-techniques/

A. P. Behera, S. Prakash, S. Khanna, S. Nigam, and S. Verma, “CNN based Metrics for Performance Evaluation of Generative Adversarial Networks,” IEEE Transactions on Artificial Intelligence, 2024, doi: 10.1109/TAI.2024.3401650.

G. Chen, Q. Chen, S. Long, W. Zhu, Z. Yuan, and Y. Wu, “Quantum convolutional neural network for image classification,” Pattern Analysis and Applications, vol. 26, no. 2, pp. 655–667, May 2023, doi: 10.1007/S10044-022-01113-Z/METRICS.

Z. Gao, X. Chen, J. Xu, R. Yu, H. Zhang, and J. Yang, “Semantically-Enhanced Feature Extraction with CLIP and Transformer Networks for Driver Fatigue Detection,” Sensors 2024, Vol. 24, Page 7948, vol. 24, no. 24, p. 7948, Dec. 2024, doi: 10.3390/S24247948.

V. Bergholm et al., “PennyLane: Automatic differentiation of hybrid quantum-classical computations,” Nov. 2018, Accessed: Apr. 14, 2025. [Online]. Available: https://arxiv.org/abs/1811.04968v4

Published
2025-04-15
How to Cite
[1]
M. Gangappa, “Quantum-Enhanced Brain Tumor Detection and Progression Prediction Using MRI Imaging”, j.electron.electromedical.eng.med.inform, vol. 7, no. 2, pp. 493-507, Apr. 2025.
Section
Electronics